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Janelia Farm Research Campus
Howard Hughes Medical Institute
19700 Helix Drive,
Ashburn, VA 20147
email: cardg\[at\]janelia.hhmi.org
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Over the past few years, we have developed tools to record the activity of genetically identified neurons in tethered Drosophila melanogaster during behavior in a virtual reality setup. We use a combination of walking and flying behavior, two-photon calcium imaging, whole-cell and loose patch clamp recording, multi-single-unit extracellular electrophysiology, genetic tools and computational analyses to understand circuit computations in a region of the insect brain called the central complex. Evidence from physiology and behavioral genetics studies suggests that this distinctively structured region of approximately one thousand stereotyped neurons is involved in visually mediated orienting, adaptive sensorimotor mapping, multisensory integration, and working memory, among other things. This motivates our choice of behaviors to investigate mechanistically on the rig.
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Vivek Jayaraman Janelia Farm Research Campus Howard Hughes Medical Institute 19700 Helix Drive, Ashburn, VA 20147 email: vivek \[A T\at] janelia.hhmi.org \\ |